Effect Of A-Lipoic Acid On Diabetic Neuropathy


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Chronic hyperglycemia is one major result of diabetes. It further produces dysregulation of both insulin action and secretion. Diabetes is a significant health issue affecting around 9% of individuals across the world. The reports established that 9 out of ten adults across the world suffer from type 2 diabetes mellitus. Thus, the researchers have made significant efforts towards increasing the awareness of this health problem along with its major risk factors but without any crucial breakthroughs. Effect of A-lipoic acid is one such research. Patients who have diabetes also tend to suffer from peripheral neuropathy.

Effect Of A-Lipoic Acid On Diabetic Neuropathy
Effect Of A-Lipoic Acid On Diabetic Neuropathy

Effect Of A-Lipoic Acid On Patients Of Diabetic Neuropathy

Peripheral neuropathy or diabetic neuropathy is quite common in people living in industrialized nations. It is also closely related to several clinical manifestations. DPN is even associated with old age, compromised glycemic control, high blood pressure, high levels of lipid, and also diabetes mellitus. But despite the wide-scale prevalence of DPN, there are hardly any treatment or prevention procedures in place. A Lipoic or Alpha Lipoic Acid works in the form of a vital co-enzyme that produces energy in the mitochondria and also has positive effects on the entire physiology of the body. The impact of A-Lipoic acid is quite good on the patients of diabetic neuropathy.

A-Lipoic acid is present in low quantities in different foods. It is also in use in the form of a pharmaceutical source and dietary supplement. When used as a dietary supplement, it is administered to the patients of type 2 diabetes in different doses. You can find its wide use for the treatment of diabetic neuropathy in these patients because of the hypoglycemic, anti-inflammatory, and antioxidant effects. Several clinical studies evaluating the ALA effect on DPN have come up with promising results as far as doing away with the symptoms of diabetic neuropathy are concerned. The impact of A-Lipoic acid on DPN has been reviewed herein.

Relevance And Objectives On Studying The Effect Of A-Lipoic Acid On Diabetic Neuropathy Patients

Diabetic neuropathy is associated with increased mortality, morbidity, and also poorly affected life quality in comparison to diabetic patients without neuropathy. Oxidative stress affects DPN pathogenesis. A-Lipoic acid is a highly potent oxidative element. It goes a long way in improving blood flow in the nerves and also reducing oxidative stress. It also helps in enhancing distal nerve conduction. A study carried out by Agathos et al. in 2018 aimed at investigating the effects of ALA on the symptoms of diabetic neuropathy in patients when administered orally.

Effect Of A-Lipoic Acid On Diabetic Neuropathy
Effect Of A-Lipoic Acid On Diabetic Neuropathy

Results Of The Study

The study revealed that there were significant reductions in the symptoms of diabetic neuropathy in patients suffering from type 2 diabetes mellitus. These patients took A-Lipoic acid orally for 40 days. After the time, there was a significant improvement in the life quality of diabetic patients with neuropathy. The study also revealed quite a good reduction in the pain and severity of the condition. However, there were mild adverse reactions, ranging from vomiting to nausea and also skin reactions.

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